Agilent 6490 Triple Quadrupole LC-MS/MS System w/ 1260 Infinity II DAD Front-End

Insights by AMPTIUS | AMP Tech Instruments

Price and cost of ownership of Agilent 6490 Triple Quadrupole LC-MS/MS

Investing in an Agilent 6490 Triple Quadrupole LC-MS/MS requires careful consideration of both the purchase price and long-term ownership costs. A new system costs approximately $322,000, while a refurbished unit with a warranty averages $110,000, offering significant savings. Beyond the initial investment, ongoing expenses include consumables such as columns, solvents, ion sources, and calibration standards, as well as regular maintenance to ensure precise and reliable results. Additional costs may include software licenses, updates, and compliance fees, particularly in regulated fields like pharmaceutical research, clinical diagnostics, and environmental analysis. Long-term ownership also involves potential service and repair expenses, which can be substantial if components such as the mass analyzer, detector, or vacuum pump require replacement. A certified refurbished Agilent 6490 provides a cost-effective alternative while maintaining reliable performance, as it undergoes comprehensive testing and comes with a warranty. For laboratories aiming to maximize their budget, balancing the upfront purchase price with ongoing operational costs is essential for long-term financial efficiency.

Labs & Universities Utilizing the Agilent 6490 LC-MS/MS for Advanced Research

The Agilent 6490 Triple Quadrupole LC-MS/MS System w/ 1260 Infinity II DAD Front-End is a powerful analytical instrument designed for ultra-sensitive quantitation in pharmaceutical, environmental, food safety, and clinical research applications. Combining triple quadrupole mass spectrometry with a diode array detector (DAD), this system enhances compound detection and structural elucidation, making it ideal for multi-analyte workflows. At the University of Colorado Anschutz Medical Campus, the School of Pharmacy's Mass Spectrometry Facility utilizes the Agilent 6490 with the 1260 Infinity II DAD Front-End for advanced proteomics, metabolomics, and small molecule analysis. Similarly, University of Victoria's Proteomics Centre, researchers have developed a multiplexed Multiple Reaction Monitoring (MRM) assay using the Agilent 6490 Triple Quadrupole MS. This assay enables the quantitation of 67 candidate cardiovascular disease biomarkers in human plasma, demonstrating the system's capability in advanced proteomics applications. With its superior sensitivity, high-throughput capabilities, and integrated DAD technology, the Agilent 6490 with 1260 Infinity II DAD Front-End remains a trusted choice for laboratories pushing the boundaries of analytical science.